Determination of O,O-Diethyl O-p-Nitrophenyl Thiophosphate (Parathion) in Pineapples
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چکیده
منابع مشابه
Cholinesterase inhibition in vitro by OO-diethyl O-p-nitrophenyl thiophosphate (parathion, E 605).
00 Diethyl 0 -p -nitrophenyl thiophosphate (I), generally known as parathion or E 605, is an insecticide which is of value against a variety of crop pests. Its mammalian toxicity is usually ascribed to its power of inhibiting cholinesterase, and this is also possibly its mechanism of insecticidal action. The in vitro inhibition of the enzyme was first studied by DuBois, Doull, Salerno & Coon (1...
متن کاملA cholinesterase inhibitor derived from OO-diethyl O-p-nitrophenyl thiophosphate in vivo.
in the urine, and the kidney must have a considerable power of concentrating formate. The inhibition of the appearance of formate during the administration ofethanol is in accordance with Zatman's (1946) interpretation of the earlier experiments, namely, that a primary oxidation of methanol to formaldehyde through the agency of alcohol dehydrogenase is competitively inhibited by ethanol. More r...
متن کاملTHE inhibition of chymotrypsin by diethyl p-nitrophenyl phosphate.
The alkyl fluorophosphonates were first shown in 1940 (Adrian, Feldberg & Kilby, 1947) to be very powerful inhibitors of cholinesterase, and for a time they were thought to be quite specific for this enzyme. Later, other esterases, such as human milk lipase and liver esterase (Webb, 1948) and citrus acetylesterase (Jansen, Nutting & Balls, 1947) were also shown to be inhibited, although not to ...
متن کاملIdentification o f a Baker-type Mechanism in Additions to p-Nitrophenyl Isothiocyanate in Diethyl Ether Solution
D M U R'NCO + RNH, ^ R ‘N = C —CT 2> R'NHCONHR (1) I + NH, I R 1 rearrangement. Subsequent work has shown that this type of mechanism is not, in fact, satisfactory for alcoholysis, and that a mechanism in which nucleophilic attack and proton transfer are concerted, and involve associated nucleophile, is likely [3, 4, 5]. Such a mechanism [equation (2) —(3)] also provides a better explanation of...
متن کاملThe inhibition of trypsin. IV. Reaction with diethyl p-nitrophenyl phosphate in the presence of urea.
The inhibition of proteolytic enzymes by organophosphorus compounds has been extensively studied in recent years (1, 2). Such studies have shown that the reaction of trypsin with diisopropyl fluorophosphate (3) or diethyl p-nitrophenyl phosphate (DENP) (4) is accompanied by a loss in the proteolytic, esterase, and amidase activities of this enzyme. It is not certain, however, whether these inhi...
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ژورنال
عنوان ژورنال: The Journal of Agriculture of the University of Puerto Rico
سال: 1969
ISSN: 2308-1759,0041-994X
DOI: 10.46429/jaupr.v39i1.12693